Abstract
Stromal cell-derived factor-1α (SDF-1α) is a chemokine that has been reported to be involved in tumor progression in several malignancies. This study aimed to evaluate the crucial role of SDF-1α in patients with esophageal squamous cell carcinoma (ESCC) who underwent esophagectomy. A total of 169 patients with ESCC were identified, including overexpression of SDF-1α in 60 patients and low expression of SDF-1α in 109 patients by immunohistochemical analysis. Two ESCC cell lines, TE1 and KYSE30, were selected to evaluate the tumor cell proliferative effect of SDF-1α. Univariate and multivariate analyses showed that high tumor (T) status, positive lymph node metastasis, tumors located in the upper esophagus, and SDF-1α overexpression were significantly related to worse disease-free survival and overall survival. In addition, the two cell lines were treated with SDF-1α, AMD3100 (an SDF-1α-ligand receptor antagonist), and chemotherapeutic agents (cisplatin). Our in vitro study results showed that SDF-1α promoted the proliferation of tumor cells, and blocking the SDF-1α pathway displayed a growth inhibition effect in a dose-dependent manner. SDF-1α plays an important role in the progression of ESCC and is an independent prognostic factor for ESCC patients who underwent esophagectomy.
Highlights
Esophageal squamous cell carcinoma (ESCC) is known to be among the most aggressive cancers.In Taiwan, ESCC accounts for 90% of esophageal cancer and is one of the top reasons for cancer-related deaths [1]
Stromal cell-derived factor-1α (SDF-1α) is a homeostatic chemokine that is constitutively expressed in several organs, and SDF-1α secretion is related to tissue damage
The TE1 and KYSE30 were treated with SDF-1α combined with chemotherapeutic agents or AMD3100, and the results demonstrate that the SDF-1α/CXCR4 axis suppresses ESCC cell growth (Figure 4)
Summary
Esophageal squamous cell carcinoma (ESCC) is known to be among the most aggressive cancers. In Taiwan, ESCC accounts for 90% of esophageal cancer and is one of the top reasons for cancer-related deaths [1]. For early-stage ESCC, radical esophagectomy is the gold-standard treatment; in spite of significant developments in medical techniques, the 5-year survival rate for patients with. ESCC who underwent esophagectomy is still poor [1,2,3]. The exploration of novel molecular prognostic models for tumor progression in ESCC is an important research priority. Stromal cell-derived factor-1α (SDF-1α) is a homeostatic chemokine that is constitutively expressed in several organs, and SDF-1α secretion is related to tissue damage.
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