Prognostic value of right ventricular Tei index and cardiac markers in sepsis

Abstract

Objective: To investigate the risk factors of death in patients with sepsis. Methods: From August 2014 to August 2016, 58 patients suffering sepsis in intensive care unit (ICU) of the People's Liberation Army 105 Hospital were prospectively analyzed.All patients were divided into survival group (n=39) and death group (n=19). The patients' gender, age, past medical history, acute physiology and chronic health system Ⅱ(APACHE Ⅱ), Sequential organ failure assessment(SOFA) score, B-type natriuretic peptide, lactate, procalcitonin, left ventricle EF%, right ventricle Tei index were measured within 24 h after admission in ICU.Logistic regression analysis was used to evaluate the risk factors of death in septic patients.the hospital mortality of sepsis was assessed by receiver operating character (ROC) curves. Results: The hospital mortality rate of sepsis was 32.8% (19/58). Logistic regression analysis showed that SOFA score [OR=2.34, 95%CI: 1.069-5.258, P<0.01], cTnI[OR=1.21, 95%CI: 1.017-1.437, P=0.032], Tei index[OR=1.56, 95%CI: 1.082-2.263, P=0.017]. The APACHEⅡ, SOFA score, lactic acid, cTnI, Tei index and cTnI combined with Tei index predicted the hospital mortality of sepsis with the area under ROC curve (AUC) of 0.821, 0.848, 0.790, 0.756, 0.962, 0.982, respectively. Conclusion: Tei index and cTnI may be the independent risk factors of sepsis in patients with sepsis, and the incidence of major adverse cardiac events was high.