Prognostic value of right ventricular free wall strain in pulmonary hypertension patients with pseudo-normalized tricuspid annular plane systolic excursion values.

Abstract

Pulmonary hypertension (PH) is a progressively fatal disease having a significant impact on right ventricular (RV) function, a major determinant of long-term outcome in PH patients. In our clinic we frequently noticed the combination of PH and reduced RV function, but with discordant Tricuspid Annular Plane Systolic Excursion (TAPSE) values. The present study focuses on whether RV free wall strain measured using 2-dimensional speckle-tracking echocardiography is able to predict mortality in this subgroup of PH patients. 57 patients with PH and RV dysfunction (visual echocardiographic assessment of ≥2) and pseudo-normalized TAPSE values (defined as ≥16mm) were retrospectively evaluated. Patients were divided by RV free -20% as cut-off value. Follow-up data on all-cause mortality were registered after a median follow-up time of 27.9±1.7months. RV free of ≥-20% was predictive of all-cause mortality after a median follow-up time of 27.9±1.7months (HR 3.76, 95% CI 1.02-13.92, p=0.05). RV free ≥-20% remained a significant predictor of all-cause mortality (HR 4.30, 95% CI 1.11-16.61, p=0.04) after adjusting for PH-specific treatment. On the contrary, TAPSE was not a significant predictor of all-cause mortality. RV free wall strain provides prognostic information in patients with PH and RV dysfunction, but with normal TAPSE values. Future studies with larger cohorts, longer follow-up periods and inclusion of more echocardiographic parameters measuring LV and RV function could confirm the strength of RV free ≥-20% as a predictor of mortality for this subgroup of patients with PH.