Abstract
BackgroundThe role of progesterone receptor (PR) has been reported in a series of pancreatic cysts. However, the relationship between PR and prognosis of solid pseudopapillary neoplasm of the pancreas (SPNP) has not been elucidated so far. The aim of our study was to evaluate the prognostic value of PR in SPNP.MethodsA total of 76 patients with SPNP treated in our institution from January 2012 to December 2017 were included. Demographic parameters, laboratory data, pathologic information and clinical outcomes were analyzed by the use of survival analysis. In addition, a pooled case series was performed to evaluate the results.ResultsThe institutional data included 76 patients (17 male and 59 female) ranging from 8 to 90 years (median, 30 years) in age. Kaplan-Meier survival analysis confirmed negative PR result was significantly associated with poorer disease-free survival (DFS) and disease-specific survival (DSS) (both P < 0.001). In the pooled analysis, a total of 62 studies comprising 214 patients with SPNP were included. After multivariable cox analysis, negative PR result remained an independent prognostic factor for SPNP (DFS HR: 14.50, 95% CI: 1.98–106.05, P = 0.008; DSS HR: 9.15, 95% CI: 1.89–44.17, P = 0.006).ConclusionOur results indicated the role of PR in predicting adverse outcome of patients with SPNP and negative PR result may serve as a potential prognostic factor.
Highlights
The role of progesterone receptor (PR) has been reported in a series of pancreatic cysts
The World Health Organization currently classifies solid pseudopapillary neoplasm of the pancreas (SPNP) as low grade pancreatic malignancy, so excellent survival result is achieved after aggressive surgical resection [5]
Our result showed that disease-free survival (DFS) and disease-specific survival (DSS) were significantly shorter in patients with negative PR result and PR was classified as an independent prognostic factor for SPNP after multivariable analysis
Summary
The role of progesterone receptor (PR) has been reported in a series of pancreatic cysts. The relationship between PR and prognosis of solid pseudopapillary neoplasm of the pancreas (SPNP) has not been elucidated so far. Solid pseudopapillary neoplasm of the pancreas (SPNP), called Frantz’s tumor, was first described in 1959 [1]. It is a rare pancreatic neoplasm of uncertain lineage, relatively indolent and female predominant, accounting for 1–2% of exocrine pancreatic neoplasms and 5% of cystic pancreatic tumors [2,3,4]. The World Health Organization currently classifies SPNP as low grade pancreatic malignancy, so excellent survival result is achieved after aggressive surgical resection [5]. Immunohistochemistry is a common method to diagnosis SPNP in pathology, and some of
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