Abstract
BackgroundSeveral studies have demonstrated that the preoperative Glasgow prognostic score (GPS) and modified GPS (mGPS) reflected the prognosis in patients undergoing curative surgery for colorectal cancer. However, there are no reports on long-term prognosis prediction using high-sensitivity mGPS (HS-GPS) in colorectal cancer. Therefore, this study aimed to calculate the prognostic value of preoperative HS-GPS in patients with colon cancer.MethodsA cohort of 595 patients with advanced resectable colon cancer managed at our institution was analysed retrospectively. HS-GPS, GPS, and mGPS were evaluated for their ability to predict prognosis based on overall survival (OS) and recurrence-free survival (RFS).ResultsIn the univariate analysis, HS-GPS was able to predict the prognosis with significant differences in OS but was not superior in assessing RFS. In the multivariate analysis of the HS-GPS model, age, pT, pN, and HS-GPS of 2 compared to HS-GPS of 0 (2 vs 0; hazard ratio [HR], 2.638; 95% confidence interval [CI], 1.046–6.650; P = 0.04) were identified as independent prognostic predictors of OS. In the multivariate analysis of the GPS model, GPS 2 vs 0 (HR, 1.444; 95% CI, 1.018–2.048; P = 0.04) and GPS 2 vs 1 (HR, 2.933; 95% CI, 1.209–7.144; P = 0.017), and in that of the mGPS model, mGPS 2 vs 0 (HR, 1.51; 95% CI, 1.066–2.140; P = 0.02) were independent prognostic predictors of OS. In each classification, GPS outperformed HS-GPS in predicting OS with a significant difference in the area under the receiver operating characteristic curve. In the multivariate analysis of the GPS model, GPS 2 vs 0 (HR, 1.537; 95% CI, 1.190–1.987; P = 0.002), and in that of the mGPS model, pN, CEA were independent prognostic predictors of RFS.ConclusionHS-GPS is useful for predicting the prognosis of resectable advanced colon cancer. However, GPS may be more useful than HS-GPS as a prognostic model for advanced colon cancer.
Highlights
Several studies have demonstrated that the preoperative Glasgow prognostic score (GPS) and modified GPS reflected the prognosis in patients undergoing curative surgery for colorectal cancer
Colorectal cancer (CRC) prognosis is based on the Union for International Cancer Control (UICC) tumour node metastasis (TNM) classification; Kasahara et al BMC Cancer (2022) 22:20 differences in outcomes have been reported among patients presenting with the same disease stage [2, 3]
Patient clinicopathological characteristics in association with GPS scores The baseline characteristics of the 595 patients who underwent curative surgery for CC are presented in Tables 1, 2, and 3
Summary
Several studies have demonstrated that the preoperative Glasgow prognostic score (GPS) and modified GPS (mGPS) reflected the prognosis in patients undergoing curative surgery for colorectal cancer. There are no reports on long-term prognosis prediction using high-sensitivity mGPS (HS-GPS) in colorectal cancer. This study aimed to calculate the prognostic value of preoperative HS-GPS in patients with colon cancer. Several studies have demonstrated that preoperative Glasgow prognostic score (GPS) and modified GPS (mGPS) reflected the prognosis in patients with CRC or colon cancer (CC) who were undergoing curative surgery [2,3,4]. There are no reports on the value of HS-mGPS in predicting long-term prognosis in patients with colorectal cancer. This study aimed to calculate the prognostic value of preoperative HS-GPS in patients with advanced resectable CC and compare it with those of GPS and mGPS
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