Prognostic value of plasma heat shock protein A12B levels in patients with multiple organ dysfunction syndrome

Abstract

Objective The aim of this study was to explore the role of heat shock protein A 12B (HSPA 12B) as a potential prognosis biomarker for multiple organ dysfunction syndrome (MODS).Methods The study involved 30 patients with MODS,including non-survivors (n=16) and survivors (n=14).Thirty patients with systemic inflammatory response syndrome (SIRS) and 15 healthy controls to evaluate the prognostic value of HSPA12B.The levels of plasma HSPA12B and interleukin (IL)-6 were measured by enzyme linked immunosorbent assay (ELISA).Results The level of plasma HSPA12B was significandy higher in patients with MODS than that in other two groups (P＜0.001).There is no differences in HSPA12B levels between SIRS patients and healthy volunteers (P=0.647).Level of HSPA12B in non-survivors was significantly higher than that in survivors (P＜0.05).Acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ)score,MODS score,Sequential organ failure assessment(SOFA) score,and length of mechanical ventilation in non-survivors were significantly higher than surviors.For prognostic value of HSPA12B,it has a area under the cure(AUC)of0.826(95％ CI:0.663-0.989,P＜0.01),significantly higher than IL-6.Conclusions Increased plasma HSPA12B within 24 h after onset of MODS can be considered as a potential prognostic biomarker in patients. Key words: Multiple organ dysfunction syndrome; Heat shock protein A12B; Prognosis