Abstract
To evaluate the prognostic impact of peritoneal washing cytology in patients with endometrial and ovarian cancers. We retrospectively identified 86 individuals with ovarian carcinomas, ovarian borderline tumors and endometrial adenocarcinomas. The patients had been treated at Shahid Sadoughi Hospital and Ramazanzadeh Radiotherapy Center, Yazd, Iran between 2004 and 2012. Survival differences were determined by Kaplan-Meier analysis. Multivariate analysis was performed using the Cox regression method. A p<0.05 value was considered statistically significant. There were 36 patients with ovarian carcinomas, 4 with borderline ovarian tumors and 46 with endometrial carcinomas. The mean age of the patients was 53.8±15.2 years. In patients with ovarian carcinoma the overall survival in the negative cytology group was better than the patients with positive cytology although this difference failed to reach statistical significance (p=0.30). At 0 to 50 months the overall survival was better in patients with endometrial adenocarcinoma and negative cytology than the patients with positive cytology but then it decreased (p=0.85). At 15 to 60 months patients with FIGO 2009 stage IA-II endometrial andocarcinoma and negative peritoneal cytology had a superior survival rate compared to 1988 IIIA and positive cytology only, although this difference failed to reach statistical significance(p=0.94). Multivariate analysis using Cox proportional hazards model showed that stage and peritoneal cytology were predictors of death. Our results show good correlation of peritoneal cytology with prognosis in patients with ovarian carcinoma. In endometrial carcinoma it had prognostic importance. Additional research is warranted.
Highlights
In South-Eastern Asia endometrial adenocarcinoma is the third most common gynecological malignancy, following cervical and ovarian carcinomas
Fariba Binesh et al we evaluated the impact of positive peritoneal cytology on the survival of patients with endometrial and ovarian malignancies
This research was approved by the university ethics committee.A retrospective chart review was performed on all patients who were diagnosed with endometrial adenocarcinoma,ovarian carcinoma and ovarian borderline tumors treated at Shahid Sadoughi Hospital and Ramazanzadeh Radiotherapy Center, Yazd, Iran
Summary
In South-Eastern Asia endometrial adenocarcinoma is the third most common gynecological malignancy, following cervical and ovarian carcinomas. The constraints of peritoneal washing cytology examination are the possibility of false positivity in benign diseases and false negativity in the early stage of the disease. In the assessment of patients with ovarian carcinoma, peritoneal cytology is an accepted method. Less is known about the prognostic impact of peritoneal cytology in endometrial carcinoma. Published researches have shown inconsistent results regarding the importance of positive cytology and survival in patients with endometrial carcinoma. Fariba Binesh et al we evaluated the impact of positive peritoneal cytology on the survival of patients with endometrial and ovarian malignancies. We analyze the survival of patients with FIGO 2009 stage IA-II endometrial carcinoma and negative peritoneal cytology in comparison to 1988 IIIA with positive cytology only.
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