Abstract
Purpose/Objective(s): Human papillomavirus (HPV) has been associated with better prognosis in several subtypes of squamous cell carcinomas of the head and neck. There is accumulating evidence to suggest that detection of p16 protein via immunohistochemistry (IHC) can be used as a surrogate marker for oncogenic variants of HPV. While there have been a few small studies examining the association of HPV and laryngeal cancer, there has been little data assessing long term clinicopathologic outcomes in this population. The purpose of this study was to investigate the prognostic value of p16 expression in early stage laryngeal cancer patients treated with radiation therapy.
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