Abstract
Background Liver biopsy is an invasive test used to diagnose chronic liver disease and to assess the degree of hepatic inflammation and fibrosis. In recent years the accuracy of noninvasive tests has increased. The aim of this study was to evaluate whether the hepatic attenuation detected at triphasic MDCT was related to the degree of cirrhosis and allow the prognosis in human patients to be established. Afterwards we have also defined the parenchymal structural alterations and vascular changes detected by CT in an animal model of hepatic cirrhosis.
Highlights
Liver biopsy is an invasive test used to diagnose chronic liver disease and to assess the degree of hepatic inflammation and fibrosis
CT findings were confirmed in the animal models, in which an altered hepatic perfusion, especially in the late phase, was detected
It was demonstrated by optical microscopy that showed high grade fibrosis and change of normal lobular structure and by electron microscopy showing modified hepatic perfusion
Summary
Liver biopsy is an invasive test used to diagnose chronic liver disease and to assess the degree of hepatic inflammation and fibrosis. In recent years the accuracy of noninvasive tests has increased. The aim of this study was to evaluate whether the hepatic attenuation detected at triphasic MDCT was related to the degree of cirrhosis and allow the prognosis in human patients to be established. Afterwards we have defined the parenchymal structural alterations and vascular changes detected by CT in an animal model of hepatic cirrhosis
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