Abstract
Background: Colorectal cancer (CRC) is one of the most common cancers in the world and the 5th leading cause of cancer death in China. CRC affects the gastrointestinal tract and has a high mortality rate. Recent studies have demonstrated the abnormal expression of miRNA-181a in a wide variety of tumors. However, the clinical significance of miRNA-181a in CRC is still unclear. Methods: The detection of miRNA-181a was performed by probe hybridization using 3' and 5' end LNA-modified DNA probes. And we evaluated the survival probabilities by the Kaplan-Meier method and the log-rank test. Furthermore, the univariate and multivariate Cox proportional hazard regression model were used for assessing the association of the miRNA-181a expression and prognosis. Results: MiRNA-181a was highly expressed in CRC (P Conclusions: These results indicated that expression levels of miRNA-181a could be an important indicator for prognosis and survival for CRC patients.
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