Abstract
BackgroundPrevious articles have reported that expression levels of microRNAs (miRNAs) are associated with survival time of patients with gastric cancer (GC). A systematic review and meta-analysis was performed to study the outcome of it.DesignMeta-analysis.MethodsEnglish studies estimating expression levels of miRNAs with any of survival curves in GC were identified up till March 19, 2017 through performing online searches in PubMed, EMBASE, Web of Science and Cochrane Database of Systematic Reviews by two authors independently. The pooled hazard ratios (HR) with 95% confidence intervals (CI) were used to estimate the correlation between miRNA expression and overall survival (OS).ResultsSixty-nine relevant articles about 26 miRNAs with 6148 patients were ultimately included. GC patients with high expression of miR-20b (HR=2.38, 95%CI=1.16-4.87), 21 (HR=1.77, 95%CI=1.01-3.08), 106b (HR=1.84, 95%CI=1.15-2.94), 196a (HR=2.66, 95%CI=1.94-3.63), 196b (HR=1.67, 95%CI=1.38-2.02), 214 (HR=1.84, 95%CI=1.27-2.67) or low expression of miR-125a (HR=2.06, 95%CI=1.26-3.37), 137 (HR=3.21, 95%CI=1.68-6.13), 141 (HR=2.47, 95%CI=1.34-4.56), 145 (HR=1.62, 95%CI=1.07-2.46), 146a (HR=2.60, 95%CI=1.63-4.13), 206 (HR=2.85, 95%CI=1.73-4.70), 218 (HR=2.61, 95%CI=1.74-3.92), 451 (HR=1.73, 95%CI=1.19-2.52), 486-5p (HR=2.45, 95%CI=1.65-3.65), 506 (HR=2.07, 95%CI=1.33-3.23) have significantly poor OS (P<0.05).ConclusionsIn summary, miR-20b, 21, 106b, 125a, 137, 141, 145, 146a, 196a, 196b, 206, 214, 218, 451, 486-5p and 506 demonstrate significantly prognostic value. Among them, miR-20b, 125a, 137, 141, 146a, 196a, 206, 218, 486-5p and 506 are strong biomarkers of prognosis in GC.
Highlights
Great quantities of previous articles have reported that expression levels of microRNAs are associated with survival time of gastric cancer (GC)www.impactjournals.com/oncotarget was under 15%, and cases of advanced GC accounted for85% [170]
GC is still the fourth most common cancer all over the world and the second most universal cause of cancer death globally, there has been a constant descent in morbidity and mortality in the past few decades [168, 169]
A novel diagnostic means and improved prognosis of GC might be created through identification of molecular aberrations, which can predict cancer progression and survival rate
Summary
Great quantities of previous articles have reported that expression levels of microRNAs (miRNAs) are associated with survival time of gastric cancer (GC)www.impactjournals.com/oncotarget was under 15%, and cases of advanced GC accounted for85% [170]. Great quantities of previous articles have reported that expression levels of microRNAs (miRNAs) are associated with survival time of gastric cancer (GC). The clinical result of GC mainly depends on the stage of tumor. Median survival time is no more than 6-9 months [171]. It is unlimited proliferation of cancer cells and ability of intense invasive and metastasis that mainly causes high malignancy degree and poorer survival time. A novel diagnostic means and improved prognosis of GC might be created through identification of molecular aberrations, which can predict cancer progression and survival rate. Previous articles have reported that expression levels of microRNAs (miRNAs) are associated with survival time of patients with gastric cancer (GC). A systematic review and meta-analysis was performed to study the outcome of it
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