Abstract
BackgroundThe anti-cancer role of metformin has been reported in many different kinds of solid tumors, but how it affects non-small cell lung cancer (NSCLC) is currently elusive. The aim of this study was to investigate the influence of metformin treatment on diabetic NSCLC.MethodsTwo hundred fifty-five patients of diabetic NSCLC receiving therapy in our hospital from 2014 to 2016 were enrolled in our study. The information on clinical diagnosis, pathology, and prognosis as well as the influence of metformin in diabetic NSCLC were collected and assessed. Univariate and multivariate analytical techniques were applied to explore how metformin affect the survival of NSCLC.ResultsOne hundred fifty of the 255 diabetic NSCLC patients took metformin. The median overall survival time (OST) and disease-free survival time (DFST) were significantly prolonged with metformin treatment compared to without metformin treatment (OST 25.0 vs 11.5 months, p = 0.005; DFST 15.6 vs 8.5 months, p = 0.010). Multivariate analysis indicated that metformin treatment could be used to predict the long-term outcome of diabetic NSCLC independently (HR = 0.588, 95% CI 0.466–0.895, p = 0.035).ConclusionOur study revealed that the metformin could help in improving the final outcome of NSCLC patients with diabetes in the long term and thus could be applied to treat NSCLC.
Highlights
The anti-cancer role of metformin has been reported in many different kinds of solid tumors, but how it affects non-small cell lung cancer (NSCLC) is currently elusive
Several studies demonstrated that the type 2 diabetes mellitus (T2DM) could be used independently to predict the outcome of breast cancer, pancreatic cancer, and gastric cancer [4,5,6,7,8]
Two hundred fifty-five patients diagnosed with NSCLC and pre-existing T2DM were enrolled in the study, and the diagnosis of NSCLC was based on the histological examination
Summary
The anti-cancer role of metformin has been reported in many different kinds of solid tumors, but how it affects non-small cell lung cancer (NSCLC) is currently elusive. The aim of this study was to investigate the influence of metformin treatment on diabetic NSCLC. The diagnosis and therapy had been greatly improved in recent decades, the optimal prognostic factors and treatment for prolonging the survival time of NSCLC still remain to be explored, due to the complexity and heterogeneity of each NSCLC patient [2]. Several studies demonstrated that the type 2 diabetes mellitus (T2DM) could be used independently to predict the outcome of breast cancer, pancreatic cancer, and gastric cancer [4,5,6,7,8]. Our study aimed at exploring how metformin affect clinical properties of a large amount of NSCLC patients, as well as the role of metformin in prognosis of diabetic NSCLC
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