Abstract
Objectives: Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor. Despite optimal treatment (maximal surgical resection, adjuvant radiotherapy and chemotherapy), the prognosis is very poor. Beside known prognostic factors, there is no method at the time of diagnosis to predict recurrence. We aimed to identify mean platelet volume (MPV) as an indicator of prognosis in GBM. Methods: One hundred and seven patients who were diagnosed with GBM histopathologically, admitted to the medical oncology clinic were included. MPV values were recorded for all patients at diagnosis. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Results: Kaplan-Meier survival curves showed that patients belonging to the high-MPV group had a worse median OS (14 month versus 20 month, P=0.004). MPV was an independent prognostic factor in GBM. Conclusions: MPV is a cheap, easily accessible and reproducible test that can be used prognostically in GBM patients before treatment.
Highlights
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor [1]
Total surgical resection followed by concurrent chemoradiotherapy and adjuvant chemotherapy constitute the optimal treatment strategy
High platelet levels have been shown to be associated with poor prognosis in many cancers.[5,6,7].Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity
Summary
The prognosis is quite poor; five-year survival rate is approximately 5%. There is no method to predict recurrence at time of diagnosis In addition to their roles in hemostasis, platelets are involved in inflammation and cancer. High platelet levels have been shown to be associated with poor prognosis in many cancers.[5,6,7].Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity. Studies found that changes in MPV values are associated with prognosis in many cancers [810]. To our knowledge there are no studies that evaluate the role of MPV values as a prognostic factor in GBM. In this study we aimed to investigate MPV values as a prognostic factor in GBM
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