Prognostic Value of Mean Platelet Volume and Platelet to Lymphocyte Ratio in Laryngeal Carcinoma

Abstract

Objective: In this study, we aimed to investigate whether platelet lymphocyte ratio (PLR) and Mean platelet volume (MPV) values can be used as prognostic and diagnostic markers in laryngeal cancer. Methods: A total of 242 patients with laryngeal pathology were reviewed retrospectively. PLR, MPV and platelet values were compared in patients with benign and malignant pathologies. The correlation of PLR, MPV and platelet values of patients with malignant pathologies with their age, gender, smoking, alcohol use, degree of differentiation, and clinical stage was investigated. Results: The PLR values were significantly higher in smokers (p=0.009), alcohol drinkers (p=0.001), clinical stage IV patients (p=0.001), and patients with poor differentiated laryngeal cancer (p=0.001), compared to nonsmokers, non­alcohol consumers, clinical stage III patients, and patients with well-differentiated laryngeal cancer. MPV values were significantly lower in patients with clinical stage IV (p=0.018), and poor differentiated (p=0.010), laryngeal cancer com­pared to patients with clinical stage III and well-differentiated laryngeal cancer. The PLR value was significantly higher in the malignant group than in the benign group (p<0.001). Conclusion: Our results showed that PLR values can be used as diagnostic and prognostic factors and MPV values can be used as prognostic factors in laryngeal cancer. J Clin Exp Invest 2016; 7 (2): 134-138