Abstract
SOX2OT has been demonstrated to be aberrantly expressed in several types of cancer and maybe serve as a prognostic marker for cancer patients. However, most individual studies have been limited by small sample sizes and controversial results. Therefore, the present meta-analysis was conducted to analyze available data to reveal the potential clinical application of SOX2OT on cancer prognosis, tumor progression, distance metastasis and lymph node metastasis. Up to February 20, 2017, literature collections were conducted by comprehensive searching electronic databases, including Cochrane Library, PubMed, Embase, BioMed Central, Springer, ScienceDirect, ISI Web of Knowledge, together with three Chinese databases: China National Knowledge Internet (CNKI), Weipu and Wanfang. The hazard ratios (HR) with 95% confidence interval (95% CI) were calculated to assess the strength of the association. Five studies with a total of 481 cancer patients were included in the present meta-analysis. The results indicated that elevated SOX2OT significantly predicted unfavorable overall survival (OS) (HR = 2.44, 95% CI: 1.75–3.39, P<0.0001) and tumor progression (III/IV vs. I/II: HR 1.62, 95%CI: 1.30–2.02, P<0.0001), but failed to predict distant metastasis (HR: 3.30, 95%CI: 0.74–14.61, P = 0.12) and lymph node metastasis (HR: 1.29, 95% CI: 0.87–1.91, P = 0.21). The results revealed that SOX2OT expression level was an independent prognostic biomarker for OS and tumor progression in Chinese cancer patients.
Highlights
Due to the increasing mobility and mortality, cancer is still a major problem for public health all over the world[1]
Articles up to February 20, 2017, which related to the Long noncoding RNAs (lncRNAs) SOX2 overlapping transcript (SOX2OT) as a potential eligible biomarker for the prognosis of cancer patients, were comprehensive searched in several electronic databases, including Cochrane Library, PubMed, Embase, BioMed Central, Springer, ScienceDirect, ISI Web of Knowledge, together with three Chinese databases: China National Knowledge Internet (CNKI), Weipu and Wanfang
Accumulating evidences have suggested that the dysregulated of cancerspecific lncRNAs could serve as novel prognostic biomarkers to more precisely evaluate the prognosis of different tumors[23]
Summary
Due to the increasing mobility and mortality, cancer is still a major problem for public health all over the world[1]. In 2017, 1,688,780 new cancer cases and 600,920 cancer deaths are projected to occur in the United States[2]. The long term survival rate remains low in various types of cancer, and numerous scientists are dedicated to searching new potential biomarkers for early diagnosis and accurate prognosis for cancer patients[3, 4]. Prognostic value of lncRNA SOX2OT for cancer outcome
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