Abstract
Background: There is a dispute on the prognostic value of long non-coding RNA regulator of reprogramming (lncRNA ROR) in cancers. The purpose of the present study was to evaluate the prognostic significance of lncRNA ROR expression in human cancers. Methods: PubMed, Embase, and Cochrane Library were searched to look for relevant studies. The meta-analyses of prognostic and clinicopathological parameters (CPs) were conducted. Results: A total of ten studies were finally included into the meta-analysis. High lncRNA ROR expression was significantly associated with shorter overall survival (hazard ratio [HR] = 2.88, 95% confidence interval [CI] = 2.16–3.84, P<0.01) and disease-free survival (HR = 3.25, 95% CI = 2.30–4.60, P<0.01) compared with low lncRNA ROR expression. Besides, high lncRNA ROR expression was obviously related to more advanced clinical stage (P<0.01), earlier tumor metastasis (P=0.02), lymph node metastasis (P<0.01), and vascular invasion (P<0.01) compared with low lncRNA ROR expression. However, there was no significant correlation between lncRNA ROR expression and other CPs, including age (P=0.18), gender (P=0.33), tumor size (P=0.25), or tumor differentiation (P=0.13). Conclusion: High lncRNA ROR expression was associated with worse prognosis in cancers. LncRNA ROR expression could serve as an unfavorable prognostic factor in various cancers.
Highlights
Despite great advancements in detection, surgical resection, chemotherapy, radiotherapy, and multidisciplinary treatments, cancer is still a critical health problem and major cause of mortality worldwide [1,2]
The results indicated that high long non-coding RNA (lncRNA) long non-coding RNA regulator of reprogramming (ROR) expression was obviously related to shorter overall survival (OS) compared with low lncRNA ROR expression in various cancers (HR = 2.88, 95% confidence interval (CI) = 2.16–3.84, P
The results demonstrated that high lncRNA ROR expression was significantly related to more advanced clinical stage (P
Summary
Despite great advancements in detection, surgical resection, chemotherapy, radiotherapy, and multidisciplinary treatments, cancer is still a critical health problem and major cause of mortality worldwide [1,2]. Many lncRNAs have been proved to associate with the prognosis of human cancers, such as metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) [3], HOXA transcript at the distal tip (HOTTIP) [4], and growth arrest-specific transcript 5 (GAS5) [11]. The purpose of the present study was to evaluate the prognostic significance of lncRNA ROR expression in human cancers. High lncRNA ROR expression was obviously related to more advanced clinical stage (P
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