Abstract
Plasma levels of human chorionic somatomammotropin (HCS) have been measured by radioimmunoassay in normal pregnancies at different gestational ages. Normal levels and standard deviations have been established. Serial determinations were also obtained in 24 diabetic patients throughout their pregnancies. HCS plasma levels observed in diabetic pregnancies are expressions of complications arising during pregnancy. Complication-free diabetic pregnancies have HCS within normal levels and always result in the birth of a living child. Pregnancies complicated by diabetic unstability (hypoglycemia, ketoacidosis, hydramnios) have HCS levels higher than normal and make it impossible to determine the infant's status. While HCS levels continue to rise, fetal death may still occur. In pregnancies complicated by maternal high blood pressure, HCS plasma levels are significantly lower than normal. In this case, it is possible to ascertain the condition of the fetus; below a certain threshold yet to be determined, fetal death may occur.
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