Abstract
Background:Ischemic stroke (IS) is a devastating occurrence affecting millions worldwide. This study aimed to evaluate the prognostic value of high-resolution magnetic resonance imaging (HRMRI) in assessing carotid atherosclerotic plaque in IS patients.Methods:Between January 2013 and March 2015, 338 IS patients were recruited for the investigative purposes of the study. All participants of the study underwent an HRMRI inspection procedure after being admitted into the hospital. During this study, we systematically analyzed and measured various types of fibrous caps, lipid compositions, and plaque lipid ratios. Univariate and multivariate logistic regression analyses were performed for predicting prognosis of IS patients. A receiver-operating characteristic (ROC) curve was employed to determine the accuracy of the IS prognosis.Results:The percentage of type I fibrous caps exhibited significant decrease, while the percentage of type III fibrous caps, lipid compositions, and lipid ratios all displayed increase. The results of the univariate analysis indicated that age, hypertension, hyperlipidemia, treatment regimens, fibrous cap type, plaque type, lipid composition, and lipid ratio shared a correlation in regards to the poor prognosis of IS patients. Multivariate logistic regression analysis demonstrated that the prognosis of IS patients was not necessarily dependent on fibrous cap type, plaque type, or age. ROC curves revealed that the HRMRI possessed a strong predicative ability in relation to the identification of the prognosis of IS patients through factors such as type of plaque and fibrous caps determination.Conclusion:Our study conclusively intimated the promise of HRMRI as an evaluative tool for the determination of carotid atherosclerotic plaques in patients with IS.
Highlights
Stroke remains a major cause of death and decrepitude worldwide, frequently rendering its victims powerless from the damage that it causes to the human body as well as motor functioning capabilities
The exclusion criteria were: ischemic stroke (IS) that was caused by fibrillation, infectious endocarditis, vasculitis, or arterial dissection; patients with malignant tumors, diseases of circulatory system, or other severe infections; patients with severe lung, heart, liver, or kidney diseases; patients that were at the time of testing in the acute phase of IS and were currently receiving thrombolysis or endovascular treatment procedures; and patients who recently underwent surgery or had a history of trauma
The results revealed the total number of plaques was 551 among 338 patients
Summary
Stroke remains a major cause of death and decrepitude worldwide, frequently rendering its victims powerless from the damage that it causes to the human body as well as motor functioning capabilities. This leads to serious economic implications as well as emotional burdens to the patients and their families.[3] The clinical causes of IS are both complicated and not fully understood, while the most common carotid atherosclerosis has been highlighted as the chief cause of IS.[4] Currently, approximately 20% of IS cases are caused by carotid atherosclerosis. This study aimed to evaluate the prognostic value of high-resolution magnetic resonance imaging (HRMRI) in assessing carotid atherosclerotic plaque in IS patients
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