Prognostic value of heart failure echocardiography index in HF patients with preserved, mid-ranged and reduced ejection fraction

Jian-Shu Chen,Cai-E Li,Tao Guo,Ying Pei,Ning-Yin Li,Jing Yu

doi:10.1186/s12872-020-01635-6

Abstract

BackgroundTo investigate the clinical value of heart failure echocardiography index (HFEI) in evaluating the cardiac function and predicting the prognosis of patients with different types of heart failure (HF).MethodsFour hundred eighty-nine consecutively admitted HF patients were divided into three groups: HF with reduced ejection (HFrEF), HF with mid-range ejection fraction (HFmrEF), and HF with preserved ejection fraction (HFpEF). The baseline characteristics and ultrasound indexes were compared between the three groups. The correlation between HFEI and one-year risk of adverse events was compared by multivariate logistic regression. The clinical value of HFEI and plasma level of NT-proBNP in assessing the prognosis of patients with chronic heart failure (CHF) was analyzed by the receiver operating characteristic (ROC) curve.ResultsHFEI in HFrEF was significantly higher than that in HFmrEF and HFpEF. Multivariate regression analysis indicated that HFEI and plasma level of NT-proBNP were independent risk factors for predicting the short-time prognosis of HF patients. The ROC curve indicated that the HFEI cutoff level of 3.5 and the plasma NT-proBNP level of 3000 pg/ml predicted a poor prognosis of CHF patients with a sensitivity of 64% and a specificity of 75% vs. 68 and 65%.ConclusionHFEI can comprehensively evaluate the overall cardiac function of patients with various types of HF, and may prove to be an important index of assessing the prognosis of HF patients.

Highlights

To investigate the clinical value of heart failure echocardiography index (HFEI) in evaluating the cardiac function and predicting the prognosis of patients with different types of heart failure (HF)
There were no significant differences in age, diastolic blood pressure (DBP), blood urea nitrogen (BUN) and αhydroxybutyrate dehydrogenase (α-HBDH) between the three groups of HF patients, while there were significant differences in HFEI and NT-proBNP between the three groups
Group D had a higher incidence of one-year adverse events than group D (Table 5). This observational study yielded the following results: (1) there were significant differences in HFEI between Heart failure with reduced ejection (HFrEF), HF with mid-range ejection fraction (HFmrEF) and HF with preserved ejection fraction (HFpEF) patients; (2) multivariate regression analysis indicated that HFEI and NT-proBNP were independent risk factors for the prognosis of oneyear adverse events in HF patients; and (3) HFEI and NT-proBNP had a good value in predicting the shortterm prognosis of HF patients

Summary

Introduction

To investigate the clinical value of heart failure echocardiography index (HFEI) in evaluating the cardiac function and predicting the prognosis of patients with different types of heart failure (HF). The global prevalence of heart failure (HF) is about 2%, with an annual incidence of 1%. With the global intensification of the aging process such as that in China, the number of HF patients continues to increase [4]. Left ventricular ejection fraction (LVEF) and the left ventricular diastolic filling (LVDF) have long been used clinically to evaluate the LV systolic and diastolic functions respectively [5, 6]. LVEF or LVDF alone is not closely related to the clinical condition and cannot

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Discussion

Conclusion