Abstract
BackgroundFibroblast growth factor receptor (FGFR) gene amplification has been reported in different types of cancer. We performed an up-to-date meta-analysis to further characterize the prognostic value of FGFR gene amplification in patients with cancer.MethodsA search of several databases, including MEDLINE (PubMed), EMBASE, Web of Science, and China National Knowledge Infrastructure, was conducted to identify studies examining the association between FGFR gene amplification and cancer. A total of 24 studies met the inclusion criteria, and overall incidence rates, hazard risk (HR), overall survival, disease-free survival, and 95% confidence intervals (CIs) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included studies.ResultsIn the meta-analysis of 24 studies, the prevalence of FGFR gene amplification was FGFR1: 0.11 (95% CI: 0.08–0.13) and FGFR2: 0.04 (95% CI: 0.02–0.06). Overall survival was significantly worse among patients with FGFR gene amplification: FGFR1 [HR 1.57 (95% CI: 1.23–1.99); p = 0.0002] and FGFR2 [HR 2.27 (95% CI: 1.73–3.00); p<0.00001].ConclusionsCurrent evidence supports the conclusion that the outcomes of patients with FGFR gene amplified cancers is worse than for those with non-FGFR gene amplified cancers.
Highlights
The fibroblast growth factor receptor (FGFR) family comprises four main members (FGFR1-FGFR4) and encodes membrane tyrosine kinase receptors involved in signaling by interacting with fibroblast growth factors [1]
For FGFR1 amplification, 9 of 17 studies were in lung cancer, 4 studies were in breast cancer, and the other 4 studies were about oral and tongue squamous cell carcinoma, and oral squamous cell carcinoma
For FGFR2 amplification, 5 of 7 studies were in gastric cancer, and the other 2 studies were in breast cancer and lung cancer
Summary
The fibroblast growth factor receptor (FGFR) family comprises four main members (FGFR1-FGFR4) and encodes membrane tyrosine kinase receptors involved in signaling by interacting with fibroblast growth factors [1]. FGFR gene amplification is frequent in breast cancer, gastric cancer and lung cancer etc. Some of other types of cancer such as oral squamous carcinoma [5], esophageal squamous cell carcinomas [6], breast cancer [7,8,9] and pancreatic cancer [10] have been reported to be associated with FGFR1 amplification. FGFR2, the second most commonly amplified gene of the FGFR family, has been shown to be amplified in gastric cancer [11,12], breast cancer [13], and non-small-cell lung cancer [14]. Fibroblast growth factor receptor (FGFR) gene amplification has been reported in different types of cancer. We performed an up-to-date meta-analysis to further characterize the prognostic value of FGFR gene amplification in patients with cancer
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