Abstract
Endogenous intoxication (EI) and oxidative stress indices were studied in Black-motley Holstein cows (n = 22) with average annual dairy productivity of 6400–7600 kg per 19–23, 28–32, and 38–45 days of gestation under physiological gestation formation, development delay, and embryo death. In cases of embryo death, the cows demonstrated blood serum concentration increase of middle molecular peptides by 23.9–34.7%, circulating immune complexes by 51.4–86.4%, and indices of endogenous intoxication by 28.8–38.0%, respectively, in comparison with physiological gestation course. In cases of development delay of embryo, the increase of these indices had the character of tendency. It is demonstrated that EI intensification in animals is connected with the activation of lipid peroxidation processes and exhaustion of antioxidant protection system.
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