Abstract
PurposeThis meta-analysis aimed to evaluate the prognostic performance of elevated lactate dehydrogenase (LDH) in patients with COVID-19.MethodsA systematic literature search was performed using PubMed, Embase and EuropePMC on 19 November...
Highlights
COVID-19 is one of the most common diseases, and the trend is rapidly increasing
Meta-regression analysis showed that diabetes was correlated with elevated Lactate dehydrogenase (LDH) (OR 1.01, p=0.038), but not age (p=0.710), male (p=0.068) and hypertension
Meta-regression analysis showed that age, male, hypertension and diabetes did not contribute to the heterogeneity of the analysis
Summary
COVID-19 is one of the most common diseases, and the trend is rapidly increasing. It has infected65.8 million people globally, resulting in over 1.5 million deaths.[1]. COVID-19 is one of the most common diseases, and the trend is rapidly increasing. 65.8 million people globally, resulting in over 1.5 million deaths.[1] Even though most of the patients with COVID-19 is only mildly symptomatic, a notable proportion of patients deteriorate remarkably, causing multiple organ failure that resulted in death.[2] Cost-effective biomarkers, especially those that are routinely tested, enable risk stratification to allow prudent resource allocation.[3]. Lactate dehydrogenase (LDH) catalyses the last step of aerobic glycolysis, the pyruvate to lactate conversion.[4] LDH has been shown to be a potential prognostic biomarker in patients with COVID-19.5
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