Prognostic Value of Different Allelic Polymorphism of Aldosterone Synthase Receptor in a Congestive Heart Failure European Continental Ancestry Population

Abstract

Patients discharged after an acute decompensation were enrolled and underwent echocardiography, determination of BNP, evaluation of non-invasive cardiac outputs and determination of -344T/C SNP in the aldosterone synthase gene. 175 patients (137 male; age 69.9±10.2years) were enrolled. The genotype distribution of -344T/C SNP demonstrated a TT genotype in 61 patients (34.9%), CTin 80 (45.7%) and finally CC in 34 (19.4%) CHF patients. According to presence of C allele, CHF patients were divided into C group (-CT/CC genotype, 114 subjects) and T Group (-TT genotype, 61 subjects). The two groups did not differ in term of age, non-invasive cardiac output at rest, creatinine level or end-systolic or diastolic left ventricle diameter, LVEF and BNP. In group C patients in comparison than in group T a higher degree of disability (Barthel Index p=0.004), NYHA class (p=0.02) and a lower cardiac index (p=0.01) emerged. Moreover, the two groups showed a similar clinical outcome (death for any cause/hospital readmission for CHF) at 48month follow-up (p=0.16; log-rank 1.99). In European continental ancestry patients the C allele (CC or CT) at-344T/C SNP in the aldosterone synthase gene does not significantly influence clinical prognosis of CHF.