Abstract
Objective The purpose of this study was to evaluate the prognostic role of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) expression level and the platelet lymphocyte ratio (PLR) level in esophageal squamous cell carcinoma (ESCC) patients. Methods 84 ESCC patients who received surgical treatment in our hospital were enrolled in the study. The correlation of each biomarker's level with ESCC patients' clinicopathological characteristics and overall survival (OS) was assessed. Results The elevated expression rate of T-CTLA-4 (tumor cell CTLA-4) and I-CTLA-4 (interstitial lymphocyte CTLA-4) was 48.8% and 44.0%, respectively. The number of enrolled patients with a higher PLR level (≥119) was 48. The prognostic value of T-CTLA-4, I-CTLA-4, and PLR in ESCC patients was not detected. However, patients with both a low T-CTLA-4 expression level and a low PLR level that had longer OS (p = 0.023) were found. The prognostic role of T-CTLA-4(-) +PLR (-) status in ESCC patients was also confirmed in multivariate analyses (p = 0.027). Conclusion These results demonstrated the potential prognostic value of combined analysis of CTLA-4 and PLR in ESCC patients.
Highlights
Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer in northern China [1, 2]
T-Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and I-CTLA-4 were mainly distributed in the cytoplasm
Kaplan-Meier analysis did not find the effects of the T-CTLA-4 expression level (p = 0 453), I-CTLA-4 expression level (p = 0 654), and platelet lymphocyte ratio (PLR) level (p = 0 703) on the overall survival (OS) in ESCC patients (Figure 3)
Summary
The purpose of this study was to evaluate the prognostic role of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) expression level and the platelet lymphocyte ratio (PLR) level in esophageal squamous cell carcinoma (ESCC) patients. The prognostic value of T-CTLA-4, I-CTLA-4, and PLR in ESCC patients was not detected. Patients with both a low T-CTLA-4 expression level and a low PLR level that had longer OS (p = 0 023) were found. The prognostic role of T-CTLA-4(-) +PLR (-) status in ESCC patients was confirmed in multivariate analyses (p = 0 027). These results demonstrated the potential prognostic value of combined analysis of CTLA-4 and PLR in ESCC patients
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