Prognostic Value of Clinical Biochemistry-Based Indexes in Nasopharyngeal Carcinoma.

Xiaojiao Zeng,Guohong Liu,Yirong Li,Yunbao Pan

doi:10.3389/fonc.2020.00146

Xiaojiao Zeng, Guohong Liu + Show 2 more

Open Access

https://doi.org/10.3389/fonc.2020.00146

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Abstract

Inflammation and nutritional status have significant effects on the prognosis of cancer patients. This study investigated the predictive value of clinical biochemistry-based indexes in nasopharyngeal carcinoma (NPC). This retrospective study included 559 NPC patients and 500 patients with chronic rhinitis. Continuous variables were measured by t-test. The area under curves (AUC) was used to determine the diagnostic and prognostic value for NPC. Kaplan-Meier methods and the log-rank test were used to analyze overall survival (OS) and disease-free survival (DFS) of the patients. Cox and logistic regression analysis were used to analyze the independent prognostic risk factors for survival and influencing factors of side effects after treatment, respectively. The study results revealed that most indexes of NPC and rhinitis were significantly different between the two groups. In the survival analysis, the systemic inflammation score (SIS), prognostic nutritional index (PNI), albumin/globulin ratio (AGR), albumin (ALB), urea nitrogen (BUN) and creatinine (CREA) had significant influence on the OS and DFS. AGR was the optimal prognostic indicator for NPC. Among these indexes, SIS, AGR, BUN and CERA were independent prognostic factors of OS, AGR and PNI were independent prognostic factors of DFS. Most indexes were risk factors of side effects occurred in radiotherapy. In conclusion, the clinical biochemistry-based indexes, are reliable and of low-cost, therefore, they can be used in predicting diagnosis, prognosis and treatment plans of NPC.

Highlights

Nasopharyngeal carcinoma (NPC) is an epithelial cancer of the nasopharynx
Based on the study results, there was a high prevalence of nasopharyngeal carcinoma (NPC) among in men and young people (Table S1)
receiver operating characteristic (ROC) curve was used to investigated the diagnostic efficacy of indexes (Figure 2A)

Summary

Introduction

Nasopharyngeal carcinoma (NPC) is an epithelial cancer of the nasopharynx. It is a rare form of cancer, it is highly prevalent in Southeast Asia and Southern China [1]. NPC staging is mainly based on the tumor-node-metastasis (TNM) staging system developed by the American Joint Cancer Committee staging (AJCC). This system is used for treatment selection, cancer control strategies and outcome prediction. Concurrent chemoradiotherapy has been regarded as the standard treatment for NPC because of the covert nature of the tumorigenic site and intrinsic sensitivity of radiotherapy [2, 3].

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