Prognostic Value of C-Reactive Protein in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Admitted to Intensive Care Unit

Abstract

Abstract Background Chronic obstructive pulmonary disease (COPD) is a leading and increasing cause of worldwide morbidity and mortality. Recently, COPD has gained interest as a major public health concern and is currently the focus of intense research because of its persistently increasing prevalence, mortality, and disease burden. COPD is the third leading cause of death in the world, and further increases in its prevalence and mortality can be predicted in the coming decades. Aim of the Work The aim of the present work was to detect the possible role of CRP levels in predicting the prognosis of ICU admitted patients with AECOPD. Patients and Methods This prospective Cross sectional study was conducted on 66 adult patients of both sexes admitted to the ICUs of Al-Mabarra governmental hospital in Port Said and Ain Shams University Hospitals. Results In our study, it was noticed that duration of NIMV (Days) ranged from 2 h - 11 days in low group and ranged from 1 day - 14 days in high group, While Duration of IMV (Days) ranged from 2 h – 7 days in low group and ranged from 3 day - 18 days in high group. In the present study, we found that 33patients were discharged after improvement (100%) from low group (it reflects the benefit of grouping our study cases), while 26patients were discharged after improvement (78.79%), and 7 patients (21.21%) unfortunately were dead from high group. In the current study, as regards the correlation between CRP with MV, ICU stay and hospital stay, it was noticed that the serum CRP level was significantly elevated in relation to increased period of IMV days (r = 0.714, p = <0.001), NIMV days (r = 0.491, p = <0.001), ICU stay (r = 0.690, p = <0.001) and hospital stay (r = 0.686, p = <0.001). Conclusion The following conclusion was obtained from the current study: CRP as biological marker was noticed to be elevated in patients with AECOPD who needed ICU admission. CRP is good indicator of future increase of MV days, hospital stay and ICU stay. There was a significant relation between CRP level and mortality. 100% of our study cases of low group discharged on improvement it reflects the benefit of grouping our study cases. There was no significant relation between CRP level and development of acute heart failure regarding the inclusion criteria in the study.