Abstract
PurposeThe aim of this study was to explore the prognostic value of baseline metabolic parameters of 18F-FDG PET/CT imaging in patients with angioimmunoblastic T-cell lymphoma (AITL).Materials and methodsFifty-six AITL patients (average age 64.0 ± 1.3 years) diagnosed pathologically from August 2009 to August 2019 were enrolled in this retrospective study. The total metabolic tumour volume (TMTV), total lesion glycolysis (TLG), maximum standardized uptake value (SUVmax), and correlated clinical characteristics were collected and analysed. TMTV was computed with the 41% SUVmax threshold method. The chi-square test or Fisher’s exact probability method was used to compare clinical characteristics. Kaplan–Meier curves were used to describe progression-free survival (PFS) and overall survival (OS). The log-rank test was used to analyse the difference within groups. The statistically significant factors in the univariate regression analysis were incorporated into the Cox risk proportional regression model for multivariate survival analysis.ResultsThe TMTV cut-off value was 514.6 cm3 from the ROC curve analysis. Forty (71.4%) patients progressed and 31 (55.4%) patients died within a median follow-up time of 19.1 (interquartile range 7.8–34.6) months. The 1-year and 3-year PFS rates were 42.9% and 30.1%, and the 3-year and 5-year OS rates were 45.9% and 34.4%, respectively. Univariate survival analysis showed that high TMTV and TLG may be the factors contributing to poor PFS and OS. Multivariate analysis showed that TMTV and prognostic index for T-cell lymphoma (PIT) were independent parameters for PFS and OS in AITL patients. TMTV, combined with PIT, may have better risk stratification performance than TMTV alone.ConclusionsBaseline TMTV and PIT were independent prognostic predictors in AITL patients. The combination of TMTV and PIT can facilitate prognostic stratification and contribute to personalized therapy.
Highlights
Angioimmunoblastic T-cell lymphoma (AITL) is the second most common subtype of peripheral T-cell lymphoma (PTCL) with distinct pathological features andGong et al EJNMMI Res (2021) 11:64 the treatment of AITL, the 5-year overall survival (OS) rate is about 32–33% [4]
Several studies have shown that baseline PET/CT metabolic parameters, such as the total metabolic tumour volume (TMTV) and total lesion glycolysis (TLG), have good prognostic value for PTCL
Study cases and clinical data Patients newly diagnosed with AITL who underwent pretreatment whole-body 18F-FDG PET/CT examination between August 2009 and August 2019 were enrolled in this retrospective study
Summary
Angioimmunoblastic T-cell lymphoma (AITL) is the second most common subtype of peripheral T-cell lymphoma (PTCL) with distinct pathological features andGong et al EJNMMI Res (2021) 11:64 the treatment of AITL, the 5-year overall survival (OS) rate is about 32–33% [4]. The prognosis of anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) is significantly better than that of other subtypes of PTCL. 18F-FDG PET/CT, which integrates anatomical and functional imaging, has great value in staging, response monitoring, and prognostication assessments of lymphoma, especially Hodgkin’s lymphoma (HL) and FDGavid non-Hodgkin’s lymphoma (NHL), such as diffuse large B-cell lymphoma (DLBCL) [8,9,10]. Several studies have shown that baseline PET/CT metabolic parameters, such as the total metabolic tumour volume (TMTV) and total lesion glycolysis (TLG), have good prognostic value for PTCL. Baseline PET/ CT metabolic parameters may have a predictive value for the prognosis of AITL. Our study aimed to explore the prognostic value of baseline quantitative metrics derived from PET/CT scans in newly diagnosed AITL patients
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