Abstract
BackgroundConflicting results on the prognostic value of blood adiponectin level in patients with coronary artery disease (CAD) have been reported. This meta-analysis aimed to investigate the prognostic value of elevated adiponectin level in CAD patients.MethodsA comprehensive literature search was conducted in PubMed and Embase databases up to May 10, 2019. Studies evaluating the association between adiponectin level and major adverse cardiovascular events (death, stroke, acute coronary syndrome or coronary revascularisation), cardiovascular mortality, and all-cause mortality in CAD patients were included. Pooled multivariable adjusted risk ratios (RR) and 95% confidence intervals (CI) was calculated for the highest vs the lowest category of adiponectin level.ResultsTwelve studies including 10,974 CAD patients were included. Elevated adiponectin level was independently associated with higher risk of cardiovascular (RR 1.93; 95% CI 1.55–2.42; p < 0.001) and all-cause mortality (RR 1.96; 95% CI 1.64–2.34; p < 0.001) in CAD patients. However, CAD patients with higher adiponectin level did not significantly increase major cardiovascular events risk (RR 1.12; 95% CI 0.86–1.45; p = 0.407) after adjustment for potential confounders.ConclusionsThis meta-analysis indicates that elevated adiponectin level is an independent predictor of cardiovascular and all-cause mortality in CAD patients. Measurement of blood adiponectin level has potential to identify CAD patients who have high risk of death.
Highlights
MethodsA comprehensive literature search was conducted in PubMed and Embase databases up to May 10, 2019
Conflicting results on the prognostic value of blood adiponectin level in patients with coronary artery disease (CAD) have been reported
Patients with CAD are under threat of subsequent cardiovascular events
Summary
A comprehensive literature search was conducted in PubMed and Embase databases up to May 10, 2019. Pooled multivariable adjusted risk ratios (RR) and 95% confidence intervals (CI) was calculated for the highest vs the lowest category of adiponectin level. Literature search This meta-analyses followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) [15]. Study selection Studies satisfied the all the following criteria were included: 1) original longitudinal studies enrolling CAD patients, 2) baseline blood adiponectin level as exposure, and, 3) reported multivariable adjusted risk ratios (RR) or hazard ratios (HR) or odds ratio (OR) with their corresponding 95% confidence intervals (CI) of all-cause or cardiovascular mortality and/or major adverse cardiovascular events (MACE) for the categorical adiponectin level during the follow-up. Exclusion criteria included the following: 1) population were not restricted in CAD patients or coexisting with CAD and other specific diseases, 2) reported risk estimate by continuous adiponectin level, 3) provided unadjusted risk estimate, and, 4) meeting abstracts, commentaries, reviews or duplicate publications
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