Abstract
BackgroundIncreased 99mTc-sestamibi stress lung-to-heart ratio (sLHR) has been shown to predict cardiac outcomes similar to pulmonary uptake of thallium. Peak heart rate and use of pharmacologic stress affect the interpretation of lung thallium uptake. The current study was performed to determine whether 99mTc-sestamibi sLHR measurements are affected by stress-related variables, and whether this in turn affects prognostic utility.MethodssLHR was determined in 718 patients undergoing 99mTc-sestamibi SPECT stress imaging. sLHR was assessed in relation to demographics, hemodynamic variables and outcomes (mean follow up 5.6 ± 1.1 years).ResultsMean sLHR was slightly greater in males than in females (P < 0.01) and also showed a weak negative correlation with age (P < 0.01) and systolic blood pressure (P < 0.01), but was unrelated to stress method or heart rate at the time of injection. In patients undergoing treadmill exercise, sLHR was also positively correlated with peak workload (P < 0.05) but inversely with double product (P < 0.05). The combined explanatory effect of sex, age and hemodynamic variables on sLHR was less than 10%. The risk of acute myocardial infarction (AMI) or death increased by a factor of 1.7–1.8 for each SD increase in unadjusted sLHR, and was unaffected by adjustment for sex, age and hemodynamic variables (hazard ratios 1.6–1.7). The area under the ROC curve for the unadjusted sLHR was 0.65 (95% CI 0.59–0.71, P < 0.0001) and was unchanged for the adjusted sLHR (0.65, 95% CI 0.61–0.72, P < 0.0001).ConclusionStress-related variables have only a weak effect on measured sLHR. Unadjusted and adjusted sLHR provide equivalent prognostic information for prediction of AMI or death.
Highlights
Increased 99mTc-sestamibi stress lung-to-heart ratio has been shown to predict cardiac outcomes similar to pulmonary uptake of thallium
Heart rate at the time of tracer injection was greater with exercise stress alone (131 ± 21 BPM) than for dipyridamole alone (87 ± 20 BPM) or dipyridamole combined with supplemental exercise (103 ± 19 BPM) (P < 0.0001)
Systolic blood pressure varied according to stress method
Summary
Increased 99mTc-sestamibi stress lung-to-heart ratio (sLHR) has been shown to predict cardiac outcomes similar to pulmonary uptake of thallium. Increased post-stress 99mTc-sestamibi lung-to-heart ratio (sLHR) has recently been shown to predict cardiac outcomes independent of other clinical and imaging variables [6]. Lung activity on exercise thallium studies is inversely related to peak heart rate and propranolol use, and the use of adjusted reference ranges has been advocated [7]. It is currently unknown how stress-related variables influence 99mTc-sestamibi sLHR and whether this in turn affects its prognostic utility and clinical interpretation
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