Abstract
Background Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a part of the mitochondrial heat shock proteins. TRAP1 expression is associated with resistance to apoptosis and therapeutic agents in multiple cancers. This study assessed TRAP1 and p53 expression in epithelial ovarian neoplasms and their association with clinicopathological parameters. p53 is a tumor-suppressor gene and key regulator of glycolysis in neoplastic cells but is mutated in tumors. Our aim was to study TRAP1 and p53 expression in epithelial ovarian neoplasms and their relation to prognostic parameters. Material and methods TRAP1 and p53 expression was evaluated in 78 cases of epithelial ovarian tumors by immunohistochemistry. Results TRAP1 expression was detected in 27 (34.62%) cases. TRAP1 expression was significantly higher in malignant cases compared with benign and borderline ones (pairwise P 0.001) and advanced FIGO stage (P=0.02) was found. A positive correlation between TRAP1 and p53 expression in epithelial ovarian tumors was detected using Pearson correlation coefficient (r=0.463; P Conclusion TRAP1 and p53 are associated with EOC carcinogenesis and poor prognosis. These molecules may have a therapeutic role in EOC.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
