Prognostic significance of tumor necrosis factor receptor-associated protein 1 and P53 in epithelial ovarian carcinoma

Abstract

Background Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a part of the mitochondrial heat shock proteins. TRAP1 expression is associated with resistance to apoptosis and therapeutic agents in multiple cancers. This study assessed TRAP1 and p53 expression in epithelial ovarian neoplasms and their association with clinicopathological parameters. p53 is a tumor-suppressor gene and key regulator of glycolysis in neoplastic cells but is mutated in tumors. Our aim was to study TRAP1 and p53 expression in epithelial ovarian neoplasms and their relation to prognostic parameters. Material and methods TRAP1 and p53 expression was evaluated in 78 cases of epithelial ovarian tumors by immunohistochemistry. Results TRAP1 expression was detected in 27 (34.62%) cases. TRAP1 expression was significantly higher in malignant cases compared with benign and borderline ones (pairwise P 0.001) and advanced FIGO stage (P=0.02) was found. A positive correlation between TRAP1 and p53 expression in epithelial ovarian tumors was detected using Pearson correlation coefficient (r=0.463; P Conclusion TRAP1 and p53 are associated with EOC carcinogenesis and poor prognosis. These molecules may have a therapeutic role in EOC.