Abstract
Aim. To analyze the prevalence of VNTR-polymorphism intron 4 (4b/4b and 4a/4b) carriage of the gene of endothelial nitric oxide synthase (eNOS) in chronic heart failure patients (CHF) of ischemic origin according to ejection fraction of the left ventricle (LVEF) and the disease stage. Material and methods. Totally, 280 CHF patients studied, selected to groups in accordance with LVEF (by echocardiography) and the disease stage. Then, within the study, genetic test specimens were collected with further typing of the gene alleles 4b/4b and 4a/4b of eNOS gene polymorphism. Results. By the prevalence analysis, 4b/4b and 4a/4b polymorphism of eNOS gene and the rate of various CHF stages in carriers, the predominance was found of 4a/4b carriers in IIА to III stages of the disease in both preserved and low LVEF. The increase of absolute risk was found, and of odds ratio of carriage of genotype 4а/4b in CHF patients with IIB-III stages. Conclusion. Genetically associated predisposition revealed to CHF progression in all patients with 4а/4b polymorphism of eNOS gene carriage and protective role of the carriage of 4b/4b eNOS polymorphism.
Highlights
Prognostic significance of the VNTR polymorphism intron 4 of the gene of nitric oxide endothelial synthase in chronic heart failure patients
To analyze the prevalence of VNTR-polymorphism intron 4 (4b/4b and 4a/4b) carriage of the gene of endothelial nitric oxide synthase in chronic heart failure patients (CHF) of ischemic origin according to ejection fraction of the left ventricle (LVEF) and the disease stage
Генотип 4a/4b в группе больных с I стадией со сниженной ФВ ЛЖ (снФВ) был определен у 1 пациента, что статистически значимо реже как по сравнению
Summary
Проанализировать распространенность носительства VNTR-полиморфизма intron 4 (4b/4b и 4a/4b) гена эндотелиальной синтазы оксида азота (eNOS) у больных с хронической сердечной недостаточностью (ХСН) ишемического генеза в зависимости от фракции выброса левого желудочка (ФВ ЛЖ) и от стадии заболевания. Aim. To analyze the prevalence of VNTR-polymorphism intron 4 (4b/4b and 4a/4b) carriage of the gene of endothelial nitric oxide synthase (eNOS) in chronic heart failure patients (CHF) of ischemic origin according to ejection fraction of the left ventricle (LVEF) and the disease stage. Несмотря на широкую освещенность в научной литературе, вопрос ассоциации VNTR-полиморфизма intron 4 гена eNOS с риском развития, прогрессирования и клиническими проявлениями ХСН остается неоднозначным и противоречивым. Цель — проанализировать частоту носительства VNTR-полиморфизма intron 4 гена eNOS у больных с ХСН ишемического генеза в зависимости от фракции выброса (ФВ) ЛЖ и от стадии заболевания
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