Prognostic significance of the angiopoietin-2 for early prediction of septic shock in severe sepsis patients.

Abstract

The current study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis. Angiopoietin-1 and -2 levels were quantified in plasma from 105 patients with severe sepsis by ELISA. Angiopoietin-2 levels elevated according to the severity of sepsis progression. Angiopoietin-2 levels were correlated with mean arterial pressure and platelets counts, total bilirubin, creatinine, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately discriminated for sepsis with an AUC=0.97 and septic shock from severe sepsis patients (AUC=0.778). Plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic shock.