Abstract
Telomeres are specialized nucleoprotein structures present at the ends of human chromosomes, andare constituted of a tandem of repeats TTAGGG. Telomere length measurement has been assessed by many previousstudies In B-Chronic Lymphocytic Leukemia patients (B-CLL). Telomere shortening was found to correlate withdisease progression. The aim of our study was to measure Telomere Length (TL) by Florescence In-SituHybridization coupled with Flow-cytometer (Flow-FISH) technique in newly diagnosed B-CLL patients. Explore itsprognostic significance, through determination of the relationship between TL; with disease stage, other prognosticmarker such as CD38 & ZAP-70 expression and patient response to treatment.
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