Abstract
BackgroundAberrant sialylated carbohydrate synthesis is frequently noted in various cancers. Sialyltransferase ST3GAL-1, which adds a sialic acid in an α-2,3 linkage to Gal β1,3 GalNAc, preforms an important role in modulating cellular behaviors. However, little is known about prognostic significance of ST3GAL-1 in clear cell renal cell carcinoma (ccRCC). In this study, we aimed to investigate the prognostic significance of sialyltransferase ST3GAL-1 and its correlation with clinical outcomes in patients with ccRCC.MethodsA total of 286 patients who underwent nephrectomy between 2005 and 2007 in a single academic center were recruited. Immunohistochemical staining was performed on tissue microarrays to assess the expression level. Kaplan-Meier method and Cox proportional hazard model were applied to assess the prognostic value of ST3GAL-1. Nomograms were generated as prediction model for overall survival and disease free survival at 5 and 8 years after nephrectomy.ResultsThe present results show high expression of ST3GAL-1 is associated with reduced overall survival (p = 0.013) and disease free survival (p = 0.004). In multivariate cox analyses, ST3GAL-1 was defined as an independent prognostic factor for overall survival (p = 0.006) and disease free survival (p = 0.001). After incorporation into the University of California Integrated Staging System (UISS) intermediate/high risk group for non-metastatic ccRCC, ST3GAL-1 could further distinguish patient with dismal prognosis (p = 0.015 and 0.002 for OS and DFS respectively). The nomograms revealed better predictive accuracy in predicting 5- and 8- year overall survival and disease free survival than the TNM stage alone.ConclusionsST3GAL-1 is an independent adverse prognostic factor for recurrence and survival of patients with ccRCC.
Highlights
Aberrant sialylated carbohydrate synthesis is frequently noted in various cancers
The upregulated sialylation may mediate key pathophysiological events during various steps of tumor progression [12,13,14]. β-galactoside α-2,3-sialyltransferase 1 (ST3GAL-1), which catalyzes the addition of sialic acid in an α-2,3 linkage to Gal β1,3 GalNAc, preforms important role in modulating cellular behavior
We aimed to investigate the prognostic significance of sialyltransferase ST3GAL-1 expression and its correlation with clinical outcomes in patients with clear cell renal cell carcinoma (ccRCC)
Summary
Sialyltransferase ST3GAL-1, which adds a sialic acid in an α-2,3 linkage to Gal β1,3 GalNAc, preforms an important role in modulating cellular behaviors. Little is known about prognostic significance of ST3GAL-1 in clear cell renal cell carcinoma (ccRCC). We aimed to investigate the prognostic significance of sialyltransferase ST3GAL-1 and its correlation with clinical outcomes in patients with ccRCC. Bai et al BMC Cancer (2015) 15:880 with the comparable stage or the same pathological type could show a wide variation in biological behavior and clinical outcomes. Abnormal high level of sialylated tumor associated carbohydrate antigens are frequently noted [10, 11]. Β-galactoside α-2,3-sialyltransferase 1 (ST3GAL-1), which catalyzes the addition of sialic acid in an α-2,3 linkage to Gal β1,3 GalNAc, preforms important role in modulating cellular behavior. Few studies dedicated to evaluate the expression of ST3GAL-1 and its correlation with ccRCC pathological characters, making the issue elusive
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