Abstract
BackgroundOsteopontin (OPN) is closely related to tumor occurrence and metastasis. This study explored the clinical value of serum OPN levels in small cell lung cancer (SCLC) patients.MethodsThe ELISA method was used to determine the OPN level of 96 SCLC patients before and after first-line chemotherapy, and compared with 60 healthy controls.ResultsThe serum OPN level of SCLC patients before treatment was significantly higher than that of the healthy control (P < 0.001). Serum OPN levels were related to disease stage, tumor size, and lymph node metastasis (P = 0.012, 0.034, and 0.037, respectively). Serum OPN level decreased after first-line chemotherapy (P = 0.019), which was related to treatment response (P = 0.011). The serum OPN level was an independent predictor of overall survival.ConclusionsThe serum OPN level can be used as a biomarker to predict treatment response and survival of SCLC patients.
Highlights
IntroductionThis study explored the clinical value of serum OPN levels in small cell lung cancer (SCLC) patients
Osteopontin (OPN) is closely related to tumor occurrence and metastasis
Patients’ characteristics Among 96 small cell lung cancer (SCLC) patients, 66 were male and 30 were female, with a median age of 55 years. 58 patients had a history of smoking, 38 had no history of smoking, 28 had limited SCLC, 58 had extensive SCLC, and 70 had lymph node metastasis
Summary
This study explored the clinical value of serum OPN levels in small cell lung cancer (SCLC) patients. Previous studies have shown that many tumors, such as pancreatic cancer, colon cancer, and NSCLC, have elevated OPN levels [9,10,11,12,13]. Studies have shown that OPN overexpression is related to tumor progression and poor prognosis [14, 15]. Many studies have shown that OPN is related to the prognosis of various cancers, the relationship between its expression and the clinicopathological characteristics of SCLC patients is still unclear. This study first evaluated the serum OPN levels of SCLC patients and healthy controls, and explored the relationship between OPN levels and treatment response and overall survival. We provide OPN as a biomarker for predicting treatment response and survival in SCLC patients
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