Abstract
Rab27 is an essential molecule of vesicle fusion and trafficking in exosome secretion process, which plays important roles in cancer progression and metastasis. Recent studies reported that Rab27 expression is also associated with cancer prognosis. Therefore, we performed a meta-analysis to reveal the prognostic significance of Rab27 expression in solid cancer. Data were extracted by searching on PubMed, Embase and Cochrane library until February 15 2020. Pooled hazard ratio (HR) with confidence interval (CI) was calculated to evaluate the association between Rab27 expression and survival in solid cancer. Ten studies with 1434 cancer patients were including for this meta-analysis. High expression of Rab27 was associated with poor survival (HR 2.67, 95% CI 1.52–4.69, p = 0.001). High expression of Rab27A was significantly associated with lymph node metastasis (HR 1.53, 95% CI 1.00–2.34, p = 0.048). High expression of Rab27B was significantly correlated with lymph node and distant metastasis (HR 2.15, 95% CI 1.56–2.95, p < 0.001; HR 6.80, 95% CI 3.12–14.85, p < 0.001), and higher TNM stage (HR 2.55, 95% CI 1.78–3.65, p < 0.001). This meta-analysis revealed that Rab27 expression could be a potential prognostic marker in solid cancer.
Highlights
Rab[27] is an essential molecule of vesicle fusion and trafficking in exosome secretion process, which plays important roles in cancer progression and metastasis
The results suggested that high expression of Rab27A was significantly associated with lymph node metastasis (HR 1.53, 95% confidence interval (CI) 1.00–2.34, p = 0.048) (Fig. 4A)
High expression of Rab27B was significantly correlated with lymph node and distant metastasis (HR 2.15, 95% CI 1.56–2.95, p < 0.001; hazard ratio (HR) 6.80, 95% CI 3.12–14.85, p < 0.001) (Fig. 5A,B), and higher TNM stage (HR 2.55, Scientific Reports | (2020) 10:14136 |
Summary
Rab[27] is an essential molecule of vesicle fusion and trafficking in exosome secretion process, which plays important roles in cancer progression and metastasis. Ten studies including 1434 cancer patients reported the association between Rab[27] expression with survival. According to the stratification by cancer type, the result of poor survival in patients with high expression of Rab[27] was consistently identified in lung cancer (HR 2.17, 95% CI 1.36–3.47, p = 0.001) and pancreatic cancer (HR 2.77, 95% CI 1.50–5.11, p = 0.001) except colorectal cancer (HR 0.90, 95% CI 0.15–5.44, p = 0.911) (Fig. 3A).
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