Abstract
The objective is to evaluate the prognostic value of preoperative magnetic resonance imaging (MRI) findings in breast cancer patients aged less than 40 years. This retrospective, single-center study evaluated 92 women aged <40 years who received a diagnosis of invasive breast carcinoma between 2008 and 2012. These patients underwent a breast MRI before treatment and follow-up at the same institution. Kaplan-Meier survival curves were used to analyze overall survival, with the log-rank test used to compare different groups. Cox regression analysis was used to estimate hazard ratios (HRs) with 95% confidence interval (95% CI) values. The mean age of the patients was 34 years (range: 25–39 years) and the mean tumor size was 3.9 cm in maximal dimension (range: 0.7–10.5 cm). Recurrence was observed in 21 (22.8%) patients and 15 (16.3%) patients did not survive during a mean follow-up period of 5.4 ± 1.9 years. MRI findings associated with worse overall survival included tumor size >5 cm (HR:5.404; 95% CI:1.922–15.198; p = 0.017), presence of non-mass enhancement (HR:3.730; 95% CI:1.274–10.922; p = 0.016) and multifocal tumor (HR:3.618; 95% CI:1.151–11.369; p = 0.028). Inconclusion, MRI findings that are suggestive of more extensive disease were associated with worse overall survival in young breast cancer patients.
Highlights
Tumor size was evaluated in 70 patients (22 patients who underwent neoadjuvant chemotherapy were not included in this analysis)
magnetic resonance imaging (MRI) Finding Mass (n = 78) Shape Round Oval Irregular Margin* Circumscribed Irregular Spiculated Kinetic curve assessment^ Persistent Plateau Washout Non-mass enhancement (n = 34) Distribution Segmental Regional Multiple regions Focal Linear Diffuse Internal enhancement pattern* Homogeneous Heterogeneous Clumped Clustered rings including 26 (28.3%) tumors that were classified as T1, 33 (35.5%) tumors that were classified as T2, and 11 (12.0%) tumors that were classified as T3
Only a few studies have evaluated prognosis in relation to breast cancer features detected with MRI
Summary
J. et al Heterogeneous Enhancement Patterns of Tumor-adjacent Parenchyma at MR Imaging Are Associated with Dysregulated. Signaling Pathways and Poor Survival in Breast Cancer. E. et al MR imaging features associated with distant metastasis-free survival of patients with invasive breast cancer: a case–control study. H. et al Invasive Breast Cancer: Prognostic Value of Peritumoral Edema Identified at Preoperative MR Imaging.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.