Abstract
Body composition of NSCLC patients remains poorly characterized in regard to NSCLC clinical characteristics. This study analysed muscle and adipose tissue compartments in respect to outcome in a large cohort of early stage NSCLC patients treated surgically within the prospective TRACERx trial. Methods: Preoperative weight and height were used to compute BMI in 375 patients with stage I-III NSCLC (8th TNM). Computed tomography (CT) scans at the 3rd lumbar vertebra were used to estimate skeletal muscle tissue compartment and provide muscle index (MI), i.e. area of the muscle (cm2)/height (m2). Associations with RNA-seq data were performed. Results: According to pre-operative BMI measures, 38% and 23% of patients were overweight or obese, respectively. There were no differences in BMI in regard to NSCLC histology, stage or gender (p>0.05). There were 44% of patients with sarcopenia, i.e. MI Conclusion: Sarcopenia does not influence the survival of early stage NSCLC patients. Increasing BMI is associated with less aggressive course of early stage NSCLC.
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