Abstract
Objective To investigate the relationship between in colorectal cancer,precancerous lesions(adenomatous polyps),and normal tissues and analyze the prognostic impact of PKC-ζ and Cortactin in colorectal cancer. Methods The expressions of PKC-ζ and Cortactin were examined by SP immunohistochemistry in colorectal cancer,colorectal adenomas and colorectal tissues adjacent to adenocarcinomas(normal tissues).Results(1)The positive rates of PKC-ζ and Cortactin in colorectal cancer tissues were significantly higher than those of colorectal tissue adjacent to adenocarcinomas(normal tissues) and colorectal adenomas(P0.05).(2)There was a significant correlation between PKC-ζ and Cortactin expression and tumor cell differentiation,invasive depth,lymph node metastasis and TNM stage(P0.05),but no statistically correlation between PKC-ζ and Cortactin expression and the age,gender,localization of tumor,tumor size and histological types(P0.05).(3)There was a positive correlation between PKC-ζ and Cortactin(r=0.574,P0.05).Conclusion PKC-ζ and Cortactin might be valuable markers in predicting the prognosis of the colorectal cancer and molecule targets for therapy.The combined detection of the PKC-ζ and Cortactin might be a more appropriate method to identify invasion and metastasis and predict the prognosis of colorectal cancer.
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