Abstract
Adenoid cystic carcinoma of salivary glands is a rare adenocarcinoma and has been placed in “high-risk” category as poor long-term prognosis. The purpose of this study was to investigate p53 protein expression in adenoid cystic carcinoma of salivary glands and its correlation with clinicopathological parameters and prognosis. Literatures were searched from PubMed, Embase, Cochrane Library and Web of Science, which investigated the relationships between p53 expression and pathological type, clinical stage, local recurrence, metastasis, nerve infiltration and overall survival. A total of 1,608 patients from 36 studies were included in the analysis. The results showed that p53-postive expression rate was 49% in adenoid cystic carcinoma of salivary glands (OR=10.34, 95%CI: 4.93-21.71, P < 0.0001). The p53-postive expression was closely related to tumor types (OR=0.30, 95%CI: 0.14-0.65, P < 0.0001). The tumor with solid histological subtype had a strong positive correlation with p53 expression. The combined analysis revealed that the p53-positive expression rate among patients in T1and T2 stage was 41.4%, compared to 53.2% among those in T3 and T4 stage. However, there was no significant correlation between tumor stage and p53 expression (OR=0.47, 95% CI: 0.17-1.29, P = 0.14). Besides, compared to patients with p53-negative expression, those with p53-positive expression had a greater chance of developing metastasis, local recurrence and nerve infiltration as well as poorer 5-year overall survival (P < 0.01). In conclusion, the p53 expression is related to the survival of adenoid cystic carcinoma of salivary glands. It can be considered as the auxiliary detection index in treatment and prognosis of adenoid cystic carcinoma of salivary glands.
Highlights
Compared to patients with p53-negative expression, those with p53-positive expression had a greater chance of developing metastasis, local recurrence and nerve infiltration as well as poorer 5-year overall survival (P < 0.01).In conclusion, the p53 expression is related to the survival of adenoid cystic carcinoma of salivary glands
The aim of this systematic review was to assess the association between p53 immunohistochemical expression and pathological types, clinical stage, local recurrence, metastasis, nerve infiltration and survival, to observe the expression of p53 in salivary glands adenoid cystic carcinoma (SACC) and its correlation with clinicopathological parameters and prognosis, which may be useful for planning the management and assessing the prognosis
The results showed that p53 was expressed at a high level in SACC tissues (OR=10.34, 95%CI: 4.9321.71, P
Summary
Constitutes approximately 4% of salivary epithelial tumors, which is the most common malignant tumor of minor salivary glands and the second most common malignant tumor involving major salivary glands. 70% of minor salivary gland tumors are malignant, and ACC is the most common type [5, 6]. It can occur at any age, but 40-60 years of age are most commonly affected, and there are slightly more women than men. Adenoid cystic carcinoma (ACC) is a rare variant of adenocarcinoma that most often arises in the salivary glands [3], and comprises www.impactjournals.com/oncotarget.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.