Prognostic significance of p16 and Smad4 deleted expression in patients with lung adenocarcinoma

Abstract

Objective To investigate the loss of p16 and Smad4 expression in human lung adenocarcinoma and their relationship with the clinicopathological characteristics and prognosis.Methods The protein expression of p16 and Smad4 in 120 cases of lung adenocarcinoma tissues was detected.The relationship between the expression of these proteins and clinicopathological features was analyzed,and the application of p16 and Smad4 in disease prognosis was evaluated.Results The loss frequency of p16 and Smad4 in lung adenocarcinoma tissues was 45.0％ and 62.5％,respectively.Loss of p16 expression was associated with lymph node metastasis (P ＜ 0.01) and clinicopathological stage (P ＜ 0.01).Loss of Smad4 expression was associated with tumor size (P ＜ 0.05),lymph node metastasis (P ＜ 0.05),and tumor differentiation (P ＜ 0.05).Loss of p16 and Smad4 expression was negatively correlated with overall survival,and the overall survival time in patients with two genetic loss was shortest (P ＜ 0.01).The Spearman correlation analysis showed that the expression of p16 had a positive correlation with the expression of Smad4 (r =0.182,P ＜ 0.05).Conclusion The loss of p1 6 and Smad4 expression in lung adenocarcinoma was associated with malignant biological behaviors and poor prognosis. Key words: p16 gene ; Smad4 gene ; Lung neoplasms ; Prognosis