Prognostic significance of P-gp, GST-π and P53 expression in gallbladder carcinoma

Abstract

AIM: To investigate the correlations of the expression of P-glycoprotein (P-gp), Glutathione-S-transferase-π (GST-π) and P53 with the clinicopathological features and prognosis of gallbladder carcinoma. METHODS: Forty-nine patients with gallbladder carcinoma who did not undergo chemotherapy before surgery were included in the study. The expression of P-gp, GST-π and P53 in gallbladder carcinoma was detected by immunohistochemistry. The correlations of Pgp, GST-π and P53 expression with the clinicopathological features and prognosis of gallbladder carcinoma were analyzed. RESULTS: The positive rates of P-gp, GST-π and P53 expression in gallbladder carcinoma were 75.5% (37/49), 65.3% (32/49), and 69.4% (34/49), respectively. There were positive correlations between P-gp and P53 expression and lymph node metastasis (both P＜0.05).The positive rate of GST-π expression in moderately or poorly differentiated carcinoma was higher than that in well-differentiated carcinoma (P＜0.05). The positive rate of P53 expression was significantly higher in carcinoma at Nevin stage S4-S5 (80.0%) than in that at Nevin stage S-S3 (80.0% vs 52.6%, P＜0.05). A significant correlation was also noted between the expression of P53 and P-gp in gallbladder carcinoma (r=0.343, P＜0.05). Patients with positive P-gp and GST-π expression had much lower survival rate than those with negative expression. CONCLUSION: Detection of P-gp, GST-π and P53 expression is of great significance for analyzing clinicopathological features and predicting prognosis of gallbladder carcinoma.