Abstract
Increasing evidence indicates that elevated neutrophil to lymphocyte ratio (NLR) are related with poor prognosis in various types of tumors. However, the prognostic role of NLR in patients with ovarian cancer (OC) remains controversial. Thus, the current meta-analysis aimed to investigate the prognostic role of NLR in patients with OC. A total of 16 studies with 4,910 patients were included. By pooling hazard ratios (HRs) with 95% confidence intervals (CIs) and odds ratios (ORs) with 95% CIs from each study. The results demonstrated that elevated pretreatment NLR was significantly related to poor OS (HR: 1.50, 95% CI: 1.27-1.77) and PFS (HR: 1.53, 95% CI: 1.28-1.84) in patients with OC. Subgroup analyses was divided by ethnicity, sample size, histologic types, cut-off value of NLR, analysis method and NOS score, but the results did not showed any significant change the main results. This meta-analysis revealed that elevated pretreatment NLR might be a predicative factor of poor prognosis in OC patients.
Highlights
Ovarian cancer (OC) is the second most common female genital tract cancer and the most lethal form of all gynecological malignancies [1]
The results demonstrated that elevated pretreatment neutrophil to lymphocyte ratio (NLR) was significantly related to poor Overall survival (OS) (HR: 1.50, 95% confidence intervals (CIs): 1.27-1.77) and Progression free survival (PFS) (HR: 1.53, 95% CI: 1.28-1.84) in patients with ovarian cancer (OC)
Many prognostic factors have been investigated in an attempt to improve treatment outcomes in OC patients, such as age, FIGO stage, residual tumor, lymph node metastasis, vascular invasion and resection margin involvement
Summary
Ovarian cancer (OC) is the second most common female genital tract cancer and the most lethal form of all gynecological malignancies [1]. The prognostic value of systemic inflammatory response markers has received paramount attention, and a variety of blood-based parameters that reflect the status of systemic inflammation have been extensively explored as prognostic biomarkers in various cancers including OC [9,10,11]. These inflammatory markers include C-reactive protein (CRP)[12], platelet count [13], neutrophil to lymphocyte ratio (NLR)[14], lymphocyte to monocyte ratio(LMR)[15], platelet to lymphocyte ratio (PLR)[16] and modified Glasgow prognostic score (mGPS)[9]
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