Abstract
Megakaryopoiesis is a process during which platelets that play a major role in hemostasis are produced due to differentiation and maturation of megakaryocytic precursors. Several genes, including oncogenes and tumor suppressor genes, play a role in the regulation of this process. This study was conducted to investigate the oncogenes and tumor suppressor genes as well as their mutations during the megakaryopoiesis process, which can lead to megakaryocytic disorders. Relevant literature was identified by a PubMed search (1998-2019) of English language papers using the terms ‘Megakaryopoiesis’, ‘Mutation’, ‘oncogenes’, and ‘Tumor Suppressor’. According to investigations, several mutations occur in the genes implicated in megakaryopoiesis, which abnormally induce or inhibit megakaryocyte production, differentiation, and maturation, leading to platelet disorders. GATA-1 is one of the important genes in megakaryopoiesis and its mutations can be considered among the factors involved in the incidence of these disorders. Considering the essential role of these genes (such as GATA- 1) in megakaryopoiesis and the involvement of their mutations in platelet disorders, study and examination of these changes can be a positive step in the diagnosis and prognosis of these diseases.
Highlights
Megakaryopoiesis is a process during which platelets that playA major role in hemostasis are produced due to differentiation and progenitors are progressively differentiated into megakaryocytes maturation of megakaryocytic precursors
Megakaryopoiesis is a process during which platelets that playMegakaryopoiesis is as a process in which bone marrow (BM)a major role in hemostasis are produced due to differentiation and progenitors are progressively differentiated into megakaryocytes maturation of megakaryocytic precursors
Several mutations occur s in the genes implicated in megakaryopoiesis, which abnormally u induce or inhibit megakaryocyte production, differentiation, and l maturation, leading to platelet disorders
Summary
A major role in hemostasis are produced due to differentiation and progenitors are progressively differentiated into megakaryocytes maturation of megakaryocytic precursors. This study was conducted to investigate the oncoly genes and tumor suppressor genes as well as their mutations during the megakaryopoiesis process, which can lead to megakaryocytic n disorders. Several mutations occur s in the genes implicated in megakaryopoiesis, which abnormally u induce or inhibit megakaryocyte production, differentiation, and l maturation, leading to platelet disorders. Considering the essential role of these genes (such as GATAr 1) in megakaryopoiesis and the involvement of their mutations in e platelet disorders, study and examination of these changes can be a positive step in the diagnosis and prognosis of these diseases. Omm Correspondence: Najmaldin Saki, Thalassemia and Hemoglobinopathy c Research Center, Research Institute of Health, Ahvaz Jundishapur - University of Medical Sciences, Ahvaz, Iran.
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