Abstract
e14662 Background: Mortalin is a heat non-inducible member of the heat shock protein 70 family that is expressed in various stress responses such as glucose deprivation, low-dose ionizing radiation, and caloric restriction. Mortalin and p53 form a complex in the cytoplasm or in the centrosome, which compromises the p53 activity, and thus prevents apoptosis under stress conditions. Methods: This study included 182 unselected Japanese patients with primary gastric cancer. The expression of mortalin and aberrant p53 was investigated by immunohistochemical staining. In addition, the human fibroblast cell line MRC-5 and the gastric cancer cell line MKN-74, which has a mutation in the TP53 gene, were grown under normal or hypoxic conditions, and changes in localization of mortalin and p53 were examined. Results: Mortalin-positive and aberrant-p53-positive samples were found in 75.2% and 62.6% of cases, respectively. The Mortalin and aberrant p53 expression was associated with tumor invasion and lymph node and l...
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