Abstract
To investigate the prognostic significance of metabolic parameters and texture analysis on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in patients with breast invasive ductal carcinoma (IDC), from August 2005 to May 2015, IDC patients who had undergone pre-treatment FDG PET/CT were enrolled. The metabolic parameters, including maximal standardized uptake value of breast tumor (SUVbt) and ipsilateral axillary lymph node (SUVln), metabolic tumor volume (MTVbt) and total lesion glycolysis (TLGbt) of breast tumor, whole-body MTV (MTVwb) and whole-body TLG (TLGwb) were recorded. Nine textural features of tumor (four co-occurrence matrices and five SUV-based statistics) were measured. The prognostic significance of above parameters and clinical factors was assessed by univariate and multivariate analyses. Thirty-five patients were enrolled. Patients with low and high MTVwb had 5-year progression-free survival (PFS) of 81.0 and 14.3% (p < 0.0001). The 5-year overall survival for low and high MTVwb was 88.5% and 43.6% (p = 0.0005). Multivariate analyses showed MTVwb was an independent prognostic factor for PFS (HR: 8.29, 95% CI: 2.17–31.64, p = 0.0020). The SUV, TLG and textural features were not independently predictive. Elevated MTVwb was an independent predictor for shorter PFS in patients with breast IDC.
Highlights
Positron emission tomography/computed tomography (PET/CT) using F-18 fluorodeoxyglucose (FDG) has been widely used for staging, recurrence detection, and assessment of response to therapy in cases of patients with breast cancer
The role of volumetric parameters derived from FDG PET/CT, such as the metabolic tumor volume (MTV) and total lesion glycolysis (TLG), has been investigated more recently
The purpose of the current study is to investigate the prognostic values of all PET image-derived parameters, including texture analysis, in patients with newly diagnosed breast invasive ductal carcinoma (IDC)
Summary
Positron emission tomography/computed tomography (PET/CT) using F-18 fluorodeoxyglucose (FDG) has been widely used for staging, recurrence detection, and assessment of response to therapy in cases of patients with breast cancer. The role of volumetric parameters derived from FDG PET/CT, such as the metabolic tumor volume (MTV) and total lesion glycolysis (TLG), has been investigated more recently. These two parameters have been shown to be independent prognostic factors for several cancers such as lung, cervical, ovarian and tonsillar cancers. Only few studies have examined the relationship between all PET image-derived parameters, including SUV, MTV, TLG and texture analysis, and patient outcome[15,16,17]. The purpose of the current study is to investigate the prognostic values of all PET image-derived parameters, including texture analysis, in patients with newly diagnosed breast invasive ductal carcinoma (IDC)
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