Abstract
This study aimed to determine the prognostic significance of low muscle volume (LMV) Bioelectrical Impedance Analysis (BIA), defined skeletal muscle index (SMI, Kg/m2 male ≤8.75, female ≤5.75) in patients undergoing potentially curative surgery for Oesophageal Cancer (OC). A prospective study of 122 patients diagnosed with OC [median age 65yr, 104 male, 65 neoadjuvant therapy] who underwent preoperative BIA (Maltron Bioscan 920). Primary outcome measure was Overall Survival (OS). LMV was identified in 11 (9.0%) of patients, which was associated with low lean muscle mass (27.3 vs. 31.1kg, p=0.012), low body fat (8.8 vs.19.3kg, p<0.001), and greater total body water (72.2 vs. 62.2%, p=0.001), and more open & close laparotomies (36.4 vs. 8.1%, p=0.012). Median and 5-year OS was 16 months and 18.2% in LMV patients, compared with 51 months and 52.4% in non-sarcopenic patients (p=0.002). On multivariable analysis of pre-operative variables, only LMV (HR 2.75; 95% CI 1.33-5.66, p=0.006) was associated with OS. BIA is an important prognostic indicator in OC and focused pre-habilitation consequently has strong potential.
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