Abstract
Several studies demonstrated that lncRNA differentiation antagonizing non-protein coding RNA (lncRNA DANCR) expression might have the potential capacity to predict the cancer prognosis; however, definite conclusion has not been obtained. The aim of this meta-analysis was to evaluate the prognostic value of lncRNA DANCR expression in cancers. PubMed, Web of Science, Scopus, and Embase were comprehensively searched for relevant studies. Studies meeting all inclusion standards were included into this meta-analysis. The analysis of overall survival (OS), disease-free survival (DFS), or clinicopathological features was conducted. Total 11 studies containing 1154 cancer patients were analyzed in this meta-analysis. The results showed, compared with low lncRNA DANCR expression, high lncRNA DANCR expression was significantly associated with shorter OS (hazard ratio [HR] = 1.85; 95% CI = 1.52–2.26; P<0.01) and DFS (HR = 1.82; 95% CI = 1.43–2.32; P<0.01) in cancers. Besides, high lncRNA DANCR expression predicted deeper tumor invasion (P<0.01), earlier lymph node metastasis (P<0.01), earlier distant metastasis (P<0.01), and more advanced clinical stage (P<0.01) compared with low lncRNA DANCR expression in cancer populations. High lncRNA DANCR expression was associated with worse prognosis compared with low lncRNA DANCR expression in cancers. LncRNA DANCR expression could serve as a prognostic factor of human cancers.
Highlights
Cancer has become a crucial public health problem and a leading cause of death worldwide [1,2]
Many studies have found that lncRNA differentiation antagonizing non-protein coding RNA (DANCR) expression might be involved with the prognosis of cancers; dispute remains for conflicting data amongst different studies [11,12,13,14,15,16,17,18,19,20,21]
We discovered that high lncRNA DANCR expression was significantly associated with shorter overall survival (OS) and disease-free survival (DFS) in cancers
Summary
Cancer has become a crucial public health problem and a leading cause of death worldwide [1,2]. A growing number of researchers begin to look for optimal biomarkers of human cancers [4,5]. LncRNAs have been proved to be closely associated with tumorigenesis, differentiation, invasion, and metastasis of cancers [8,9]. LncRNA differentiation antagonizing non-protein coding RNA (lncRNA DANCR), a kind of lncRNA, is located on human chromosome 4 [10]. Accumulating studies have supported a substantial role of lncRNA DANCR expression in the cancer prognosis [11,12,13,14,15,16,17,18,19,20,21]. We conducted this systematic review and meta-analysis to determine the prognostic value of lncRNA DANCR expression in cancers
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