Abstract
BackgroundThe purpose of this study was to investigate the correlation between human epidermal growth factor receptor 2 (HER2) overexpression and clinicopathologic factors and overall survival rate in patients who underwent curative gastrectomy for gastric adenocarcinoma.MethodsAmong patients who underwent curative gastrectomy for gastric adenocarcinoma at Inje University Paik Hospital from January 2012 to December 2015, 782 patients underwent an immunohistochemical analysis to evaluate HER2 expression levels. Clinicopathologic records that were collected from a gastric cancer database were retrospectively reviewed to identify clinicopathologic factors and survival rates of the patients.ResultsHER2 overexpression was detected in 166 patients (21.2%). There was a statistically significant correlation between HER2 expression level and sex (p = 0.013), histologic differentiation (p < 0.001), Lauren classification (p < 0.001), and T pathologic stage (p = 0.022). There were no statistically significant relationships between HER2 expression level and overall 5-year survival rate (p = 0.775) and overall 5-year survival rate of gastric adenocarcinoma classified according to the TNM stage (stage I: p = 0.756, stage II: p = 0.571, stage III: p = 0.704). The HER2 expression level was not affected by the overall 5-year survival rate in the uni- and multivariate analyses.ConclusionsIn this study, the HER2 overexpression rate in gastric adenocarcinoma was 21.2% and was observed in well- and moderately differentiated types according to histologic differentiation, intestinal type according to the Lauren classification, male, and low T stage. There was no correlation between HER2 expression level and overall 5-year survival rate, and HER2 expression level was not associated with independent prognostic factors.
Highlights
In Korea, the detection rate of early gastric cancer has increased from 24.8 to 57.6% over the past 20 years due to the implementation of national checkups and the development of diagnostic techniques [1]
human epidermal growth factor receptor 2 (HER2) overexpression was predominantly observed in males, well- and moderately differentiated type according to the histologic differentiation, the intestinal-type according to Lauren classification, and low T stage
There was no correlation between HER2 expression level and overall 5-year survival rate, regardless of the classification method
Summary
In Korea, the detection rate of early gastric cancer has increased from 24.8 to 57.6% over the past 20 years due to the implementation of national checkups and the development of diagnostic techniques [1]. The overall 5-year survival rate of gastric cancer has. Human epidermal growth factor receptor 2 (HER2), a target used in breast cancer treatment, is the second member of the epidermal growth factor receptor (EGFR) family and is a type of receptor tyrosine kinase. It is a 185-kD glycoprotein that was discovered when the NEU oncogene was studied in rats. The purpose of this study was to investigate the correlation between human epidermal growth factor receptor 2 (HER2) overexpression and clinicopathologic factors and overall survival rate in patients who underwent curative gastrectomy for gastric adenocarcinoma
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