Abstract
BackgroundDefects in Human Leukocyte Antigen (HLA) class I antigen expression and/or function in tumor cells have been extensively investigated, because of their potential role in the escape of tumor cells from T cell recognition and destruction. The researchers evaluated HLA class I expression in tumor tissue as a prognostic factor in osteosarcoma patients and as a predictor of their survival. This retrospective cohort study was conducted at the pathology laboratory of Ain Shams University Hospital, and Ain Shams University Specialized Hospital during the period between January 2009 and January 2012.MethodsThe researchers investigated HLA class I expression in primary osteosarcoma by immunohistochemistry using EMR8-5 mAbs. Furthermore, researchers evaluated the correlation between HLA class I expression and the clinicopathological status and outcome in formalin fixed paraffin embedded tissues from thirty six (36) patients with osteosarcoma.ResultsA high expression of HLA class I was detected in 18 (50) % of tumor samples examined; while tumors with low or negative expression represented 9 (25%) cases each. Data indicate that the overall survival rate of patients with tumors highly expressing HLA class I was significantly higher than those with low or negative expression.ConclusionDown-regulation of class I antigen expression is associated with features of aggressive disease and a poorer prognosis. Therefore, it is imperative to identify HLA as a prognostic factor at the time of diagnosis to detect chemotherapy-resistant tumors and to generate a modified treatment regimen.Virtual slidesThe virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1159334857109547.
Highlights
Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents with a high metastatic potential [1,2] comprising approximately 20% of overall bone tumors and about 5% of pediatric tumors [3,4]
The objective of this study is to evaluate Human Leukocyte Antigen (HLA) class I EMR8-5 as a potential prognostic factor in osteosarcoma patients at time of diagnosis that is capable of predicting their survival
A highly significant relationship was found between HLA class I expression and the sex of the patients (P = .000); all cases showing high HLA class I expression were males (Table 1)
Summary
Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents with a high metastatic potential [1,2] comprising approximately 20% of overall bone tumors and about 5% of pediatric tumors [3,4]. Depending on the predominant type of extracellular matrix, conventional osteosarcoma is classified into osteoblastic, chondroblastic and fibroblastic [9] This separation is largely artificial, because there is no statistical difference in the survival of patients with high-grade tumors among these 3 histologic types. The researchers evaluated HLA class I expression in tumor tissue as a prognostic factor in osteosarcoma patients and as a predictor of their survival. This retrospective cohort study was conducted at the pathology laboratory of Ain Shams University Hospital, and Ain Shams University Specialized Hospital during the period between January 2009 and January 2012
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